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Galectin-8 Enhances T cell Response by Promotion of Antigen Internalization and Processing
(Cell Press, 2020-07)
Galectin-8 (Gal-8) is a mammalian lectin endowed with immunostimulatory ability. In the present work, we demonstrate that Gal-8-glycan interactions on the surface of antigen-presenting cells (APCs) promote antigen binding ...
Editorial: Emergent Effects of Noise in Biology: From Gene Expression to Cell Motility
(Frontiers Media S.A., 2019-05)
Deterministic modeling coarse-grains unitary events into population behavior, however this approach often misses the diversity of responses in cellular and molecular systems, due to long-time effects of stochastic fluctuations. ...
Pulsing Dendritic Cells with Whole Tumor Cell Lysates
(Springer, 2014-03)
One of the strategies employed in immunotherapy for cancer is to use of ex vivo-generated dendritic cells (DC) pulsed with tumor antigens. Several approaches have been used to obtain and load tumor antigens in DC. One such ...
Assessment of biological effectiveness of boron neutron capture therapy in primary and metastatic melanoma cell lines
(Taylor & Francis Ltd, 2014-08)
Purpose: In order to optimize the effectiveness of Boron Neutron Capture Therapy (BNCT), Relative Biological Effectiveness (RBE) and Compound Biological Effectiveness (CBE) were determined in two human melanoma cell lines, ...
Editorial: Addressing roles for glycans in immunology using chemical biology
(Frontiers Media S.A., 2020-06)
Glycoconjugates, macromolecules containing carbohydrates (glycans) conjugated to proteins or lipids, are a diverse class of biopolymers capable of regulating cell-cell interactions. They are present in a high, natural ...
Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
(Elsevier Science, 2020-12)
Linalool and 1,8-cineole are plant-derived isoprenoids with anticancer activities in lung cancer cells, nevertheless, the cellular and molecular mechanisms of action remain poorly understood. The purpose of this study was ...
Purification of Recombinant Galectins Expressed in Bacteria
(Cell Press, 2020-12)
Galectins are soluble lectins that participate in many physiological and pathological functions. Since they can act extracellularly, the use of the recombinant protein is a recurrent strategy for studying their biological ...
Influence of individual cell motility on the 2D front roughness dynamics of tumour cell colonies
(Springer, 2014-06)
The dynamics of in situ 2D HeLa cell quasi-linear and quasi-radial colony fronts in a standard culture medium is investigated. For quasi-radial colonies, as the cell population increased, a kinetic transition from an ...
Insights into Stem Cell Factor chemotactic guidance of neural crest cells revealed by a real-time directionality-based assay
(Elsevier Gmbh, 2012-05)
The extracellular environment through which neural crest cells (NCCs) translocate and differentiate plays a crucial role in the determination of cell migration and homing. In the trunk, NCC-derived melanocyte precursor ...
Sequential and synchronized hypertonicity-induced activation of Rel-family transcription factors is required for osmoprotection in renal cells
(Elsevier, 2018-12)
NF-κB and TonEBP belong to the Rel-superfamily of transcription factors. Several specific stimuli, including hypertonicity which is a key factor for renal physiology, are able to activate them. It has been reported that, ...